Inflammation in the Pathogenesis of Chronic Diseases

In this book, a worldwide panel of leading experts discuss the role of inflammation in the pathogenesis of major chronic diseases and the current controversy regarding risk versus benefit of selective cyclooxygenase-2 (COX-2) inhibitors. The authors provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future of medicine, including historical perspectives on the discovery and development of aspirin, ibuprofen, and compounds that selectively inhibit COX-2, and the potential for development of new compounds with better efficacy and safety in the 21st century. Specific chapters illuminate the role of inflammatory mechanisms in the pathogenesis of arthritis, cardiovascular disease, cancer, neurodegenerative disease, diabetes mellitus, obesity, and other life-threatening and debilitating conditions. In addition, important findings are documented in cancer research and a special section explores the current evidence supporting the role of COX-2 and inflammation in the development of Alzheimer?s disease and other neurodegenerative conditions and the potential benefit of compounds that modulate COX-2 and other inflammatory cytokines.

Scientists in medical research specializing in studies of arthritis, cardiovascular disease, cancer, neurodegenerative disease, diabetes mellitus, inflammation, nutrition and obesity., professionals in medicine, pharmacy, allied health, public health, and basic science., libraries of medicine and medical research., pharmaceutical industry