Together B6, B12 and folic acid have been found to reduce levels of homocysteine, a risk factor of heart disease. High levels of homocysteine allow for the build up of plaque in the arteries and over time this damage can lead to atherosclerosis.This team of B vitamins may prevent such action, improving circulation and lowering heart disease risk. Folic acid is needed for energy production, immune support and formation of red blood cells. Folic acid is a B vitamin important for the prevention of certain birth defects (fetal neural tube defects) and it works with B6 and B12 to prevent high homocysteine levels.