Glucosamine sulfate stimulates the manufacture of glycosaminoglycans (GAGs), key components of cartilage. Significant reductions in joint pain, stiffness, tenderness, and swelling as well as increased joint performance are the hallmarks of glucosamine sulfate. Chondroitin sulfate is involved in attracting nutrient-rich fluid into the cartilage. Too little water in cartilage can cause dryness, pain and loss of nutrients in the joints. Chondroitin works well with glucosamine to improve the structural integrity of cartilage and joints. Chondroitin also inhibits the formation of enzymes that break down joint tissue, theoretically allowing growth and strengthening to take place.The dual action of glucosamine and chondroitin sulfate supports healthy cartilage at a cellular level. Each supplement is effective on its own; however, when used together, they more effectively arrest the process of osteoarthritis and encourage cartilage stabilization.