This book is based on an in-depth filmed conversation between Howard Burton and Stephen Scherer, the GlaxoSmithKline Research Chair in Genome Sciences at the Hospital for Sick Children and University of Toronto. Stephen Scherer discusses his lifelong passion for science that culminated in his groundbreaking discovery of copy-number variation. This conversation also covers his exciting work in autism research and how copy number variation brings us a deeper understanding of both human variability and disease. This carefully-edited book includes an introduction, More Things in DNA, Horatio..., and questions for discussion at the end of each chapter: I. James Watson’s Legacy - From The Double Helix to NRC to chromosome 7 II. In the Lab - The first hints of copy number variation III. Chromosome 7 - Mapping genetic markers to chromosomes IV. Back to Basics - Nucleotides, DNA, chromosomes, genes and mutations V. Revolutionary Stirrings - Detecting copy number variation VI. Going Global - Large-scale variation for all VII. Variability and Evolution - Appreciating biological variability VIII. Causes and Implications - Complexity galore: autism and other conditions IX. Towards Treatment - Early diagnoses and equilibrium-restoring medicines X. The Definition of Diseases - More complicated that you might think XI. Probing Deeper - Stem cells, pleiotropy and environmental factors XII. Ethical and Societal Issues - Towards responsible progress XIII. Future Possibilities - Potentially unravelling biological complexity XIV. Contact with Autism - Serendipitous occurrences XV. Nobel Thoughts - The perks and perils of prizes XVI. The Human Condition - Genetic windows on humanity About Ideas Roadshow Conversations Series: This book is part of an expanding series of 100+ Ideas Roadshow conversations, each one presenting a wealth of candid insights from a leading expert through a focused yet informal setting to give non-specialists a uniquely accessible window into frontline research and scholarship that wouldn't otherwise be encountered through standard lectures and textbooks. For other books in this series visit our website (https://ideas-on-film.com/ideasroadshow/).